CPZ and hepatocellular carcinoma: Additionally, through the pretreatment of cells with endocytosis inhibitors, including AHH (macropinocytosis), FIII (caveola-mediated endocytosis), or CPZ (clathrin-mediated endocytosis) [32], we found that LPPC activates different endocytosis pathways, especially the caveola-mediated pathway, to increase cellular uptake of BP in HCC cells, thereby causing cell death.