For osteolysis-specific DEmRNAs, intracellular signaling cascade (p = 1.80E − 02), cell adhesion (p = 8.45E − 04), plasma membrane (p = 9.54E − 05), and cytoskeletal protein binding (p = 1.08E − 02) were several significantly enriched GO terms, and hematopoietic cell lineage (p = 1.35E − 02), cell adhesion molecules (CAMs) (p = 2.29E − 02), porphyrin and chlorophyll metabolism (p = 3.40E − 02), and systemic lupus erythematosus (p = 4.86E − 02) were significantly enriched KEGG pathways (Figures S3, S4 C–F). The gene discussed is DNM2; the disease is systemic lupus erythematosus.