Mittal et al. [3] think that besides the cavitation effect caused by ultrasonic irradiation of microbubbles, it can damage microvessels, and the possible reasons include that cavitation effect can promote the absorption of paclitaxel by tumor tissues, promote the apoptosis of tumor cells, and reduce the secretion of angiogenic factors such as VEGF, thus reducing angiogenesis. This evidence concerns the gene VEGFA and neoplasm.