Such BDNF/TrkB [37] integration leads to the activation of some signaling pathways including extracellular signal-regulated kinase 1/2 (ERK1/2) which is consistent with our findings that CRS-induced depressive-like behaviors and the consequent downregulation of BDNF/TrkB and ERK1/2 activity could be reversed by AGO administration. Here, FBXW7 is linked to congenital rubella syndrome.