In this study, hub genes in the PPI networks were identified for the substantia nigra (SLC6A3, SLC18A2, and TH), putamen (BMP4 and SNAP25), prefrontal cortex area (SNAP25), and cingulate gyrus (CTGF, CDH1, and COL5A1) of PD through the cytoHubba plug-in. The gene discussed is CCN2; the disease is Parkinson disease.