Treatment with 11 R-VIVIT or cyclosporine A significantly decreased insulin-mediated migration of vascular smooth muscle cells, increased transcription in vascular smooth muscle cells mediated by NFAT, NOD, and hyperinsulinemia, and NFAT inhibitors reduce hyperinsulinemia and NOD ligand-induced inflammatory responses in vascular smooth muscle cells (58). The gene discussed is INS; the disease is Hyperinsulinemia.