Interestingly, even in the context of AD, where beneficial effects of ADAM10 or its activation were shown by many laboratories in AD animal models (Postina et al., 2004; Tippmann et al., 2009; Zhang et al., 2013; Corbett et al., 2015; Meng et al., 2017) administration of GI254023X showed neuroprotective potential (Shackleton et al., 2016). Here, ADAM10 is linked to Alzheimer disease.