In this segment, although PDX1 gene knockdown/knockout (Kimmel et al., 2015; Wiggenhauser et al., 2020) gains a high score of eight, this does not reveal insulin resistance symptoms, making this model better suited for studying T1DM (Saberzadeh-Ardestani et al., 2018). The gene discussed is INS; the disease is type 1 diabetes mellitus.