YTHDF1 and cancer: The genetic alterations and copy numbers of YTHDF1 were analyzed using the cBioPortal (cBio Cancer Genomics Portal3) (Cerami et al., 2012; Gao et al., 2013), which indicated that the YTHDF1 gene was frequently amplified and the mRNA expression of YTHDF1 had a positive correlation with its copy number in TCGA cohort (P < 0.001, r = 0.7106, Figure 1C).