With a particular focus on metastasis, a number of scientific studies were able to provide evidence that an implication of LRH-1 overexpression enhances metastatic potential as well as invasion of cancer cells, contributing to a more aggressive malignant phenotype in different types of human cancer, including gastric cancer (Liu et al., 2019), pancreatic cancer (Lin et al., 2014a), ovarian cancer (Sun et al., 2020), lung cancer (Ye et al., 2019), and colon cancer (Yan et al., 2017). The gene discussed is NR5A2; the disease is lung cancer.