PRNP and Alzheimer disease: PrPC has putatively high affinity for Aβ oligomers and has been suggested to induce neurotoxic processes through the mediation of Aβ toxicity (Laurén et al., 2009; Salazar et al., 2017; Brody and Strittmatter, 2018; Purro et al., 2018; Zhang et al., 2019), leading to the impairment of synaptic plasticity and defects in LTP in AD (Freir et al., 2011).