MAPT and Alzheimer disease: This has been consistently observed in many protein systems including Aβ (Walsh et al., 2002) and tau (Ward Sarah et al., 2012) in AD, αSyn (Winner et al., 2011) in PD and human islet amyloid polypeptide (IAPP) in type II diabetes (Abedini et al., 2016; Scollo and La Rosa, 2020).