LDHA and breast cancer: In order to determine the function of piR-823 in regulating CSCs in breast cancer, we analyzed the change in the ALDH + CSC subpopulation in MCF-7 cells after piR-823 knockdown (Figure 3A), indicating a decreased CSC proportion from ∼1.6 to 0.5% following knockdown of piR-823 (Figure 3B).