At the genetic level, tumor mutation burden (Cao et al., 2019) and alterations in DNA damage response and repair genes including ATM, ERCC2, BRAC-2, FANCA, MSH6, and POLE can to some extent predict the response of ICIs in specific cancer types (Teo et al., 2018; Fares et al., 2019). This evidence concerns the gene POLE and neoplasm.