BRCA1 and cancer: For example, mutations in the protein p53, which binds other proteins mainly via disordered interactions, are found in many types of cancer including cancers of the colon, lung, breast, and brain (Hollstein et al., 1991), while mutations in the IDP breast cancer type 1 susceptibility protein (BRCA1) are, as the name suggests, often implicated in breast cancer (Semmler et al., 2019).