Consistent with a retrospective study on 251 Korean patients with PBC, age, Child–Pugh score, serum levels of TBIL, DBIL, ALB, Hb, and plasma creatinine, WBC and PLT counts, PT/INR, hemorrhage from esophageal or gastric varices, and hepatic encephalopathy were found to be associated with poor prognosis in patients with PBC [38]. This evidence concerns the gene GSTM1 and primary biliary cholangitis.