Although IL-8-mediated thrombocytopenia has not been investigated in malaria, a significant body of evidence suggests its involvement in platelet production, destruction, and/or activation (Broxmeyer et al., 1996; Bounameaux et al., 2007; Tsirigotis et al., 2016; Zhang et al., 2019). The gene discussed is CXCL8; the disease is malaria.