In advanced HIV disease, adrenal exhaustion, infection with opportunistic pathogens, and development of anti-corticosteroid and anti-adrenal gland cells antibodies (Salim et al., 1988; Sinha et al., 2011) often low level of ACTH are considered as potential mechanisms for progression to overt adrenal insufficiency even when no apparent lesion with medical imagery. The gene discussed is POMC; the disease is infection.