Roifman et al. reported that 3 brothers suffered from combined immunodeficiency (CID) due to a homozygous mutation (c.C1191A/p.Y397X) in the RELB gene (Mericoa et al., 2015; Sharfe et al., 2015; Ovadia et al., 2017). The gene discussed is RELB; the disease is combined immunodeficiency.