Initially, SARS-CoV-2 mediated infection is dependent on the viral S1 domain binding to ACE2 and their cleavage by the transmembrane serine protease 2 (TMPRSS2), whereas the viral S2 domain is responsible for conformational changes that drive the fusion process between viral and host cell membranes (Brest et al., 2020; Wang et al., 2020a). The gene discussed is TMPRSS2; the disease is infection.