The IRAK1 gene is the key encoder of the intracellular signaling pathway of TLR/IL-1R and assists the recognition of viruses by TLR7/8 and the production of IFN- α, being one of the main genes that contribute to the divergence of responses related to gender after trauma and sepsis (Gottipati et al., 2008; Sperry et al., 2014). Here, IL1R1 is linked to Sepsis.