TMPRSS2 and viral infectious disease: Additionally, single nucleotide polymorphisms (SNPs) were investigated for ADAM17 and TMPRSS2, indicating that some TMPRSS2 genotypes are more susceptible to other viral infections, such as H1N1, while ADAM17 expression quantitative trait loci are related to the modulation of the ACE2 shedding process (Brest et al., 2020).