ACE2 and infection: A peculiarity of SARS-CoV-2 is the surface protein (Spike, S) (Figure 1), which mediates virus recognition by human cells, that has a 10- to 20-fold higher affinity to ACE2 in comparison to the surface proteins of SARS-CoV, which contributes to its high infection and dissemination rates (Gheblawi et al., 2020).