These observations suggest that targeting CYP24A1 might be the key pathway to improve the sensitivity of CRC to vitamin D. MicroRNAs have been implicated in the antitumor effect of vitamin D. For instance, calcitriol upregulates miR-627, which further suppresses the expression of KDM3A, a histone demethylase resulting in inhibition of cell proliferation by negatively regulating several proliferation-associated genes (41). This evidence concerns the gene CYP24A1 and colorectal carcinoma.