CYP24A1 and colorectal carcinoma: In addition, overexpression of miR-1278 increased the sensitivity of CRC cells to vitamin D, which showed a robust antitumor effect on CRC, by suppressing the expression of CYP24A1, the main enzyme determining the biological effect of vitamin D. Furthermore, miR-1278 mimic led to inhibition of metastasis by upregulation of BTG2.