As shown in Figures 4F,G, downregulating KDM2B and EZH2 in HT-29 and DLD-1 cells decreased the expression of phosphorylated PI3K and phosphorylated AKT and increased the expression of PI3K and AKT, suggesting that the downregulation of KDM2B and EZH2 activates the PI3K-AKT signaling pathway in CRC. The gene discussed is KDM2B; the disease is colorectal carcinoma.