EZH2 and colorectal carcinoma: To elucidate the functional relationship between KDM2B and EZH2 in CRC, we selectively silenced the KDM2B gene via the lentiviral expression vector of short hairpin RNA (shRNA) against KDM2B (shKDM2B) and negative control (NC) in HT-29 and DLD-1 cells.