• Younger patients:    ° R-CHOP    ° CNS prophylaxis to high-risk groups (testicular, renal, adrenal)    ° CNS involvement: intrathecal chemotherapy/hig-dose methotrexate    ° More intensive {[DA-EPOCH-R (rituximab, etoposide phosphate, prednisone, vincristine sulfate (Oncovin), cyclophosphamide, and doxorubicin hydrochloride) or R-ACVBP (adriamycin, cyclophosphamide, vindesine, bleomycin, prednisone, rituximab)]} for high-risk or double hit    ° Delay radiotherapy • Elderly patients:    ° R-mini CHOP • G-CSF to minimize neutropenia. The gene discussed is CSF3; the disease is Decreased total neutrophil count.