CSF3 and B-cell chronic lymphocytic leukemia: • Radiotherapy for limited disease • Anti CD20 • Anti CD20-CVP (cyclophosphamide, vincristine, prednisolone) or anti CD20-CHOP (cyclophosphamide, doxorubicin hydrochloride, vincristine, prednisone) preferred to anti CD20-bendamustine • For small lymphocytic lymphoma/marginal zone/mantle cell, give oral targeted therapy (e.g., ibrutinib ± anti CD-20) • G-CSF to shorten neutropenia • IVIG for patients with low IgG levels and recurrent infections