The tumor suppressor gene p53 (p = 1.6e-05, Wilcoxon Test, Figure 4B) and the kinases ARID1A (p = 0.0007, Wilcoxon Test, Figure 4B) and RNF43 (p = 0.00012, Wilcoxon Test, Figure 4B) showed the strongest single-gene associations with a TIP in terms of selection probability (Figure 4A), indicating these genes to be relevant factors for the TIPs inflamed (tumor, CD4) (TP53, RNF43) and inflamed (tumor, CD8) (ARID1A), respectively. Here, CD8A is linked to neoplasm.