It has been found extracellular HSP70 could activate ERK1/2, NF-kB, and proinflammatory genes transcription in lung cancer cell, and in breast cancer, tumor-educated B cells could target HSPA4 to promote lymph node metastasis through Src/NF-kB pathway [27, 28]. The gene discussed is NFKB1; the disease is breast carcinoma.