Figure 1(b) indicates the correlation coefficient among the 28 immune cell types. We can find some highly correlated immune cell couples in this figure, such as Th2 cells/CD56 NK cells, monocyte/memory B cells and Tregs/activated dendritic cells. We clustered glioma samples according to the ssGSEA scores of these immune-associated gene sets and divided them into two distinct clusters: high_infiltration and low_infiltration (Figures 1(c)–1(d)). Results confirmed that patients with high-infiltration TMEs had worse clinical outcomes than those with low-infiltration TMEs (Figure 1(e)). This evidence concerns the gene NCAM1 and central nervous system cancer.