The underrepresentation of deleterious SLC39A8 mutations had also been observed in 60,706 subjects from the Exome Aggregation Consortium (Lek et al., 2016), which was consistent with pathogenicity of ZIP8 mutations leading to a genetic disorder with a recessive inheritance pattern (Boycott et al., 2015; Park et al., 2015). Here, SLC39A8 is linked to hereditary disease.