To analyze risk factors affecting the prognosis of GBM patients, univariate Cox’s analysis was performed and the result showed that the prognosis of GBM patients was associated with age, IDH1 mutation, MGMT methylation, CIMP methylation, and the six-mRNA signature, but not with gender and KPS (Karnofsky) score. Here, IDH1 is linked to glioblastoma.