Our univariate analysis of the TCGA cohort showed that age, IDH1 mutation, MGMT methylated, and CIMP methylated were significantly associated with OS of GBM patients, which is consistent with numerous previous studies (Hegi et al., 2008; Cohen et al., 2013; de Souza et al., 2018). The gene discussed is IDH1; the disease is glioblastoma.