In addition, genetic variations in two coding regions of Apolipoprotein L1 (APOL1) and Heme oxygenase 1 (HMOX1) genes have been associated to chronic kidney disease (Genovese et al., 2010; Tzur et al., 2010), and to SCD nephropathy (Saraf et al., 2015; Schaefer et al., 2016). The gene discussed is HMOX1; the disease is chronic kidney disease.