However, it is interesting that unlike most other types of tumors, the expression level of ITGA9 obviously declines in hepatocellular carcinoma and works as an inhibitor of the migration and invasion of hepatocellular carcinoma cells via the FAK/Src (c-Src tyrosine kinase)-Rho GTPases signalling pathway (77). This evidence concerns the gene ITGA9 and hepatocellular carcinoma.