The nanoparticle-mediated delivery of ITGA9 siRNA into tumor cells has the capacity to sharply down-regulate angiogenesis, growth and metastasis by inducing β-catenin degradation via the integrin-linked kinase (ILK)/protein kinase A (PKA)/glycogen synthase kinase 3 (GSK3) pathway (69). This evidence concerns the gene ILK and neoplasm.