ITGA9 and cancer: The expression of miR-125b is clearly decreased in primary melanoma, and even less so in the metastatic invasion phenotype, which is negatively correlated with the expression of ITGA9. Integrin-α9β1 advances cancer growth and metastasis by potentiating EMT (64) so that miR-125b shows the capacity to inhibit malignant melanoma cell invasion and metastasis by targeting ITGA9 in vitro and in vivo (67).