Nucleic acid sensors toll-like receptor 7 (TLR7), toll-like receptor 9 (TLR9), absent in melanoma 2 inflammasome (AIM2), and cyclic GMP-AMP synthase (cGAS) have been implicated in PAMP detection, subsequently activating inflammatory pathway cascades and causing the production and release of pro-inflammatory cytokines such as type I interferons, IL-1β, IL-6, and IL-12 (33–35). The gene discussed is TLR9; the disease is melanoma.