A previous study showed in non-small cell lung cancer cells (NSCLC) that Ak4 stabilizes Hif1α protein through inhibition of prolyl hydroxylase (PHD) (22), our data suggest that Ak4 not only stabilizes Hif1α protein but also enhances its transcription (Figure 3C; Supplementary Figures 3D,H). This evidence concerns the gene PDC and non-small cell lung carcinoma.