In conclusion, our results indicate that TREM-1 expression levels in CD14+ monocytes associate with both decreased FcγR activity and autophagy levels resulting in decreased differentiation to M2 type regulatory macrophages upon anti-TNF mAb treatment, which may explain anti-TNF non-response in IBD patients with high expression levels of TREM-1. Here, FCGR2A is linked to inflammatory bowel disease.