RORC and acromegaly: Importantly, the study of EMT has provided some interesting biomarkers to predict SRLs response in acromegaly, for example, E-cadherin and RORC. Furthermore, as we could only glimpse for now, EMT in acromegaly is involved in a lot of processes like stemness, apoptosis, secretory vesicles trafficking, cytoskeleton organization, invasion capacities and aberrant splicing.