PLAT and androgen insensitivity syndrome: Additionally, each hour without treatment results in a person losing the amount of neurons that would normally take 3.6 years to be lost (3), leading to the popularly referenced motto “time is brain.” Treatment with alteplase or tissue plasminogen activator (tPA) for Acute Ischemic Stroke (AIS) has been a proven treatment since the mid 1990's (4).