Treatment with 3K3A-APC alone or 3K3A-APC in combination with tPA reduced the infarct volume determined at 7 days by 62–66% (MCAO in aged mice) and 50–53%, (embolic stroke in spontaneously hypertensive rats), as well as improved behavior (p < 0.05) and significantly reduced tPA-induced intracerebral microhemorrhages (Figure 4). Here, PLAT is linked to stroke disorder.