APOE and diabetes mellitus: Further analysis indicated that compared to people with neither diabetes nor TOMM40 G, individuals with diabetes alone had a significantly lower MMSE score in model 1 (β: −1.18, 95% CI: −1.189 to −0.47, p = 0.001) and people having both diabetes and TOMM40 G had a markedly lower MMSE score in model 1 (β: −2.10, 95% CI: −3.49 to −0.71, p = 0.003), and the results were similar in the fully adjusted model (Figure 1B); moreover, these associations were independent of the APOE polymorphism.