The APOE ε4 carriers and non-carriers did not differ significantly in the mean age and years of education, or in the distribution of sex, current smoking, alcohol intake, physical inactivity, obesity, high cholesterol, high triglycerides, low HDL-C, high LDL-C, hypertension, diabetes, depression, and heart disease (for all comparisons, p > 0.05). This evidence concerns the gene APOE and obesity due to melanocortin 4 receptor deficiency.