Causing autosomal dominant congenital eye malformations (incl. microphthalmia, anophthalmia, and coloboma disease) (Chou et al., 2015)poor binding of mutated RBP4 to retinol but higher affinity to STRA6 (Chou et al., 2015). This evidence concerns the gene STRA6 and Anophthalmia.