It is interesting to note that mutations in the RBP4 receptor STRA6 in humans cause a wide array of malformations including anophthalmia, congenital heart defects, diaphragmatic hernia, alveolar capillary dysplasia, lung hypoplasia, and intellectual disability, also referred to as Matthew-Wood syndrome (Golzio et al., 2007; Pasutto et al., 2007; Chassaing et al., 2009). The gene discussed is STRA6; the disease is Anophthalmia.