RBP4 and cardiovascular disorder: Cardiovascular system and blood pressure. Circulating RBP4 levels also correlate with blood pressure and cardiovascular disease (Solini et al., 2009; Meisinger et al., 2011; Sun et al., 2013; Li et al., 2019), potentially also secondary to decreased renal clearance due to hypertensive nephropathy (Majerczyk et al., 2017).