It was reported that lapatinib-resistant HER2+ breast cancer cells increased the expression levels of survivin and c-IAP2, two inhibitors of apoptosis (IAPs), and treatment with the mTOR kinase inhibitor AZD8055 reversed expression of IAPs and overcame lapatinib resistance in lapatinib-resistant cells (Brady et al., 2015). This evidence concerns the gene ERBB2 and breast cancer.