At present, several clinical trials, including the SAFIR study (NCT02379247), BEECH study (NCT01625286) and IPATunity130 (NCT03337724), are ongoing to assess the effect of the PI3Kα inhibitor alpelisib or AKT inhibitor of AZD5363 or ipasertib plus paclitaxel in advanced BC or mBC. The gene discussed is AKT1; the disease is breast cancer.