The Ban-Xia-Hou-Pu decoction plays an antidepressant role by inhibiting the activation of NLRP3 inflammasomes and the production of IL-1β in the liver, hypothalamus, hippocampus, or prefrontal cortex of CUMS-induced depression rats (Jia et al., 2017). This evidence concerns the gene NLRP3 and major depressive disorder.