Of the 136 studies, 45 reported antibiotics as one of the main treatment strategies for COVID-19, 58 for antivirals, 43 for corticosteroids, 27 for chloroquine or hydroxychloroquine, 19 for immunoglobulins, nine for interferons, 15 for RRT, 14 for tocilizumab, and less than five for IL-6 antagonist, immunomodulators, or immune enhancers. This evidence concerns the gene IL6 and COVID-19.