RNA-seq analysis of four prefrontal cortex subregions from 52 PTSD subjects and 46 control subjects revealed the downregulation of ELFN1 and GABA-related genes such as GAD2 (glutamate decarboxylase 2), SST, PNOC (prepronociceptin), and SLC32A1 (VGAT) in the dorsolateral prefrontal cortex (dlPFC) of PTSD patients. The gene discussed is ELFN1; the disease is post-traumatic stress disorder.