Study found that magnetic resonance (MR)-guided MB enhanced low intensity pulsed FUS (LIFU) transiently open the BBB and delivers a liposome loaded MGMT inhibitor, O6-(4-bromothenyl) guanine (O6BTG) in mice bearing TMZ-resistant gliomas, thereby sensitizing murine and human gliomas to TMZ both in vivo and in vitro (Papachristodoulou et al., 2019). The gene discussed is MGMT; the disease is central nervous system cancer.