Similarly, co-infection of glioma cells with both anti-angiogenic gene therapy vectors Ad-Flk1-Fc, which expresses a soluble VEGF receptor and oncolytic virus dl922/947 whose replication and subsequent cytotoxicity are restricted to cancer cells, yielded significantly higher anti-glioma effect than monotherapy (Thorne et al., 2006). The gene discussed is KDR; the disease is glioma.