Based on these alterations, four pediatric HGG subtypes can be distinguished: H3.3-K27M; H3.1-K27M, characteristic of high grade midline gliomas, including diffuse intrinsic pontine glioma (DIPG); H3.3G34-R/V; and BRAF-V600E (Jones et al., 2017). This evidence concerns the gene BRAF and diffuse intrinsic pontine glioma.