TP53 and central nervous system cancer: RAS, PI3K/PTEN/AKT, RB/CDK N2A-p16INK4a, and TP53/MDM2/MDM 4/CDKN2A-p14ARF pathways are commonly activated in gliomas and has been involved in cancer cells proliferation (Nakada et al., 2011; Crespo et al., 2015).