IDH1 and central nervous system cancer: Pediatric gliomas are mostly wt-IDH1, and they also can harbor TP53 and ATRX inactivating mutations, additionally mutations in H3F3A, HIST1H3B, HIST1H3C, and BRAF (Rapidly Accelerated Fibrosarcoma type B) are frequent in pediatric high-grade gliomas (HGGs) (Bjerke et al., 2013; Venteicher et al., 2017).