NR2E1 and central nervous system cancer: A LV encoding a shRNA specific for TLX, an orphan nuclear receptor (NR2E1), essential for neural-stem cell renewal, inhibited human glioma stem cell tumorigenicity in mice, and induced the expression of DNA hydroxylase ten eleven translocation 3 (TET3), a potent tumor suppressor downstream of TLX (Cui et al., 2016).