Although blocking the immune checkpoints with anti-PD-1, anti-PD-L1 and anti-CTLA4 has shown promising results and is an effective strategy for many other types of cancers, their ability to bolster the immune response is limited in the case of GBM (Woroniecka and Fecci, 2018; Woroniecka et al., 2018). The gene discussed is CD274; the disease is glioblastoma.