CD274 and neoplasm: Currently, therapies targeting the classical immune checkpoint pathways responsible for inducing the exhausted T cell phenotype, PD-1 to PD-L1 and CD80/CD86 to CTLA4, are being used to reverse the dysfunctional state and enhance anti-tumor immune response (Kamran et al., 2017; Woroniecka and Fecci, 2018; Woroniecka et al., 2018).