Similarly, down-regulation of integrin α(v)β(3) expression and integrin-mediated signaling in glioma cells by adenoviral transfer of antisense urokinase-type plasminogen activator receptor and wild type p16 cDNA resulted in decrease adhesion, migration, proliferation and enhanced survival (Adachi et al., 2001, 2002). The gene discussed is CDKN2A; the disease is central nervous system cancer.