RYR2 and catecholaminergic polymorphic ventricular tachycardia: Hence, we generated a RyR2V3599K/+ mouse model with a single amino acid substitution in the CaM-binding domain of RyR2, and crossed it to the CPVT–associated RyR2R2474S/+ mouse to obtain an RyR2R2474S/+/V3599K/+ mouse.