TMC5 and head and neck squamous cell carcinoma: We used the TCGA database to verify the bioinformatics findings of the 47 differentially expressed genes screened, and found that, among the 47 screened genes, the significant up-regulation or down-regulation of EGFR, CHL1, TRIM13, CDH26, WFDC2, MUC4, ALDH3A1, CLIC6, TPPP3, TMC5 and SERPINB3 in head and neck squamous cell carcinoma were compared with normal samples (Fig. 6).