ARMC4 may inhibit the proliferation and division of NPC cells by participating in the Cilium pathway, Coiled coil pathway and repeat: ARM 6 pathway, etc. Many diseases are strongly associated with ARMC4, such as Kartagener syndrome, paranasal sinus diseases, rhinitis, sinusitis, recurrent otitis media, nasal inflammation, and respiratory insufficiency due to defective ciliary clearance, recurrent respiratory infections, primary ciliary dyskinesia(23), autosomal recessive predisposition, and recurrent sinus disease, all of which have direct or indirect relations to NPC. Here, ODAD2 is linked to Respiratory insufficiency.