It is noteworthy that the Ckidney, 4 hr of endogenous IS in febuxostat-administered intact rats was higher than that in the vehicle-administered adenine-induced acute renal failure rats (Fig. 1 and Supplemental Table 2), indicating that febuxostat largely inhibited IS transport from the epithelial cell to lumen via ABCG2. Here, ABCG2 is linked to acute kidney injury.