CGAS and neoplasm: IFNA, IFNB and CXCL10 transcript levels were decreased in TRAMP-C2 and DU145 cells transfected with cGAS siRNAs and cGAS-deficient A549, HeLa, and HCT116 cells (Fig. 3C) demonstrating that sensing of cytosolic DNA by cGAS contributes to the constitutive expression of type I IFNs in tumor cells.