Cytosolic dsDNA and RNA:DNA hybrids partially co-localized with cGAS in all tested tumor cells (Figs. S3 and S4).To demonstrate that cGAS physically binds to dsDNA and RNA:DNA hybrids in tumor cells, cytosolic dsDNA and RNA:DNA hybrids were immunoprecipitated in A549 cells. The gene discussed is CGAS; the disease is neoplasm.