Compared to sedentary demyelinated mice, wheel running following demyelination increased proteins associated with metabolism (e.g. Ndufb9: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9, Pgam2: phosphoglycerate mutase 2), glutathione anti-oxidant responses (Mgst1: microsomal glutathione S-transferase 1), transmission across chemical synapse (e.g. Ncald: neurocalcin delta) and proteolytic activity (e.g. ADAM10: a disintegrin and metalloprotease 10, Serpin1b: leukocyte elastase inhibitor B) (Fig. 4C, Supplementary Figure 3). This evidence concerns the gene PGAM2 and Peripheral demyelination.