In contrast to the vascular phenotype, HFD-induced renal alterations were comparable in EC-EGFR-WT and VSMC-EGFR-WT animals, reflecting the metabolic syndrome (reduced estimated glomerular filtration, albuminuria, glomerulosclerosis and a shift in the transcriptome in response to the enhanced lipid load). Here, EGFR is linked to glomerulosclerosis.