Surprisingly, aortae from EC-EGFR-WT animals responded to HFD with a mild endothelial dysfunction only in the abdominal aorta, an effect that was absent in abdominal aortae from EC-EGFR-KO animals, probably due to the preexisting mild endothelial dysfunction (Fig. 4A–D). Here, EGFR is linked to endothelial dysfunction.