HFD-induced cardiovascular effects are virtually identical in EC-EGFR-WT and EC-EGFR-KO animals, with the exception of the mild endothelial dysfunction of abdominal aorta that was not observed in EC-EGFR-KO, most probably due to the already preexisting endothelial dysfunction (Fig. 3). Here, EGFR is linked to endothelial dysfunction.