The present study investigates in vivo and ex vivo the role of EC-EGFR under basal conditions as well as during high fat diet-induced obesity/diabetes mellitus type 2 (DMT2) using the (B6.Cg-Tg(Tek-cre)1Ywa/J = Tie2CRE)16 mouse model to generate EGFR deletion, with respect to vascular remodeling, vascular gene expression and renal damage. The gene discussed is EGFR; the disease is obesity due to melanocortin 4 receptor deficiency.