CD4 and systemic lupus erythematosus: Consistent with previous transcriptomic studies of SLE CD4+ T cells, we found that ISG signature in these cells was associated with JAK-STAT, T cell co-stimulation pathways and tissue homing signatures24 (Fig. 1 and Supplementary Fig. 1), indicating that chronic type I IFN signaling may promote CD4+ T cell response.