Prior to studying the potential link between type I IFN signaling and mitochondrial abnormalities, we applied a combination of in silico and in vitro methods to stratify the SLE patients according to the degree of the type I IFN signaling: high level of ISGs (IFN-High), low level of ISGs (IFN-Low), and no ISGs (IFN-Neg). Here, IFNA1 is linked to systemic lupus erythematosus.