INS and metabolic dysfunction-associated steatotic liver disease: By the use of the Kyoto Encyclopedia of Genes and Genomes (KEGG) database, the PRD-specific active genes were enriched in several metabolic pathways, inducing those associated with protein processing in the endoplasmic reticulum, nonalcoholic fatty liver disease (NAFLD), ribosomes, insulin signaling and cholesterol metabolism, in the livers of both 4-week-old and 7-week-old mouse, as shown in Fig. 2e.